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It remains to be seen whether these observed variations are attributable to differences in biological susceptibility to specific pollutants between boys and girls, to other potential differences between sexes (e.g., amount of exposure to air pollutants, differing susceptibility to viruses, varying parental approaches to illness based on sex), or to chance variation.
The team bred mice to create strains with differing susceptibility to a strain of West Nile that infects humans.
Genes predicted to be causal for atherosclerotic lesion size in genetic crosses of mice with differing susceptibility to atherosclerosis were identified [17] based on (i) the correlation between transcript levels and lesion size, (ii) the overlap of expression and atherosclerosis QTLs and (iii) the likelihood of a causal rather than a dependent or reactive relationship based on Bayesian modeling.
These mechanisms may result in differing susceptibility to specific biomechanical forces, leading to a heterogeneous pathological profile.
Among the population the variability in β-defensins copy number, specifically hBD3, may result in differing susceptibility of some individuals to disease-induced inflammation 39, 40.
This study is the first to have identified discrete sets of DE genes in pigs of differing susceptibility to H. parasuis infection.
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Therefore, the variation in MRJ-L expression in macrophages among different individuals results in differing susceptibilities to HIV-1 infection.
We derived a lineage of cell lines with markedly differing susceptibilities, unexplained by PrPC expression differences, to identify such factors.
Because of their differing amino acid sequences, the CS1 and CS2 domains have differing susceptibilities to proteolysis.
Since cord blood samples from several different donors were used for reconstitution it may account for differing susceptibilities of mature human cells to DENV infection in NOD-scid IL2rγnull mice, which could contribute to the lack of consistent findings of dengue disease in our mice.
No one would think of inducing informative sets of mutations in people, but nature has already performed the experiment by shaping the human population into groups with differing susceptibilities to disease.
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