Twenty years later, Lands further divided the β-adrenergic family into β1 and β2 receptors based on differing specificities for these same agonists on fatty acid mobilization, and bronchiodilation and vasodepression, also in whole organs (2).
The analysis indicated that despite the mAbs' differing specificities for cocaine, the relative contributions of the steric (∼80%) and electrostatic (∼20%) field interactions to ligand-binding were similar.
One theory for the large number of TIR1 homologs is that although IAA is the major form of auxin, there may be other structurally different forms of natural auxin playing roles in developmental processes, with AFB proteins providing differing specificity for these compounds [8].
H2O2 production is countered by Trx and GSH/glutaredoxin (Grx) systems, both functioning to reduce disulfides, but with differing specificities for protein Cys (62, 65).
A single ancestral form gave rise to all the members of each aaRS class, despite differing specificity for amino acids, through several duplication and divergence events [ 35].
We used FN, Fg and VN as ligands with differing specificity for αv integrins and collagen as a non-αv integrin ligand.
This difference, in addition to the differing specificities for pyridine nucleotide substrate, may have contributed to the overall TyrAa divergence observed between the two Actinobacteridae groups.
The 'classical' collagenases (MMP-1, MMP-8 and MMP-13) have differing substrate specificities for collagens I, II and III, with MMP-13 showing a preference for type II collagen [ 6].
All three PHD isoforms regulate both HIF-1α and HIF-2α, but differ in expression patterns, specificities for the two different prolyl hydroxylation sites within the HIF-1α and 2α subunits, and a degree of selectivity between HIF-α isoforms (Appelhoff et al. 2004, Raval et al. 2005).
