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This might be explained in part by the differing sites of action of the ER stressors.
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Drug interactions may reveal mechanisms of drug action: additive interactions suggest a common site of action, and synergistic interactions suggest different sites of action.
Toluene acts as a central nervous system depressant, and it is likely that all volatile solvents act similarly, although potency and sites of action may differ between solvent type.
In turn, it opens up the possibility of selective drug targeting and also illustrates well that 7TM receptor splice variants should be considered important, as their pharmacological profiles and sites of action may differ.
Hence, Ca2+ serves as a messenger during both phases of the cellular response, but its cellular sites of action, its mechanisms of generation, and its molecular targets differ during the initial and sustained phases of the response.
However, several modes of action as well as multiple sites of action have been proposed.[3].
Thyrotoxicosis involves two sites of action of the thyroid hormone.
Evidence points to the involvement of multiple sites of action.
Various mechanisms of actions, including peripheral and central sites of action, have been discussed for its antinociceptive action [ 66].
Antibiotics may have multiple sites of action in bacterial cell.
K201 has multiple sites of action in the heart.
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