The structure of PTB domains confers specificity for binding peptides having a NPXY motif with differing requirements for phosphorylation of the tyrosine within this recognition sequence.
We start with a brief discussion of region definitions and the scenarios where different regions have differing requirements for a MRCT.
Perhaps different proteins have differing requirements for BM-derived co-factors for amyloid formation.
This facilitated a trial with a simple primary endpoint (response rate) but precluded examination with any subtlety of the differing requirements for palliative and neoadjuvant treatment.
Versatile and economically competitive thermal energy storages are necessary to fulfill the widely differing requirements for storages applied in renewable energy systems, process heat, district heating, power generation and domestic heating.
The model is used to discuss a number of issues relevant to the design of effective metal sandwich plates, including differing requirements for air and water environments, face sheet shear-off resistance, the role of core strength, and the relation between small-scale tests and full-scale behavior.
The findings highlight the differing requirements of the multi-professional rehabilitation interventions for the various SLE phenotypes in order to optimize the clinical care of the patients.
By using morpholinos to reduce htt levels in the developing zebrafish, we have demonstrated that neuronal cells have differing requirements for htt function.
Our work highlights the fact that diverse modes of acute liver injury have differing requirements for RIP1 and RIP3; moreover, within a single injury model, RIP1 and RIP3 blockade can have diametrically opposite effects on tissue damage, suggesting that interference with distinct components of the necrosome must be considered separately.
