This concept reconciles the apparently contradictory results that widely differing preparations of Aβ exert similar cytotoxic effects, and offers the therapeutic potential for targeting the key conformation with small molecules or monoclonal antibodies.
The first of these, coordinated by Wehmiller (this edition), used homogeneous hydrolysates of Pleistocene mollusc and eggshell materials and focused on the agreement of analytical measurements between laboratories, without interference from differing sample preparation procedures.
With subgroup analysis of the flexible sigmoidoscopy versus colonoscopy group to exclude possible effects of differing bowel preparation, c-kit staining (flexible sigmoidoscopy 5.5; 3.4 6 vs colonoscopy 3.9; 2.6–4.5) did not differ significantly (p = 0.2) between the two groups.
In fact, different preparations differ both in the intrinsic periods of the neurons involved as well as the synaptic plasticity profiles.
Physical dose variation between differing nanoparticle preparations and cell lines can be seen to be much smaller than predicted, highlighting this as an unknown in cellular radiobiological response which is not driven by increasing the total dose delivered to the cells behind the radiosensitizing properties of gold nanoparticles (Butterworth et al. 2013).
As the results indicate differing surfactant preparations to reveal distinct effects on lung function variables, further studies are needed to define an optimized surfactant composition.
The properties of HAP differ with preparation route, reaction ingredients, etc.
(iii) Requirement of standardized reference systems for differentiated hepatic cells At present, pHHs are well-established reference cells, but their metabolic capacity can strongly differ among preparations (Hewitt et al. 2007).
Previous recommendations in the medical literature for low cost phantoms have recommended a preparation method differing from ballistic gelatin in concentration and preparation temperature [1, 5].
We compared ChEP preparations differing as a result of regulated physiological changes within the cell.
