Multiple risk estimates were listed separately for each study and identified separately for differing outcomes and drugs, for example, all bisphosphonates/alendronate and category of cancer: (1) esophageal, (2) gastric or (3) UGI cancer.
11 22 We found considerable heterogeneity in both studies of incidence and prognosis, arising from differences of population selection, differing outcomes and measurement of and adjustment for confounders.
In this regard, there is precedence for differing outcomes with HBO.
These differing outcomes may be accounted for in part by the low prevalence of T2D (3%), the low prevalence of vascular calcification 32-566%) and low mortality rate (~3% all-cause, <1% CVD) in the earlier study by Allison et al. compared to the DHS cohort (100% T2D affected; 78-96% with vascular calcification; 22% mortality).
The possibility of equally valid simulations having differing outcomes means that standard techniques for comparing numerical accuracy are inappropriate.
Only two papers were judged to be of sufficient quality to have been fully able to include in explanatory meta-analyses (with appropriate sensitivity analyses for blinding) if differing outcomes had not prevented these from occurring (Table 2).
Despite extensive research, the prognosis for workers remains variable, with differing outcomes on health and employment.
Differing biological outcomes for ASH2L and WDR5 from DPY-30 and RBBP5 are surprising because these four proteins are core components of the same SET1/MLL1−4 methyltransferases.
The aim of the present study was to compare cases of operable node-negative breast cancer, matched by time and place of diagnosis and treatment, but differing by outcome, for a range of putative prognostic markers and to derive empirically an index that distinguished most accurately patients destined for long-term disease-free survival from those who would suffer early distant relapse.
We will develop a predictive model for our principal outcome measure (cumulative number of work disability days during the year after claim submission) and additional predictive models for the secondary outcomes (e.g., one-year work status, functional status), because the models may differ for different outcomes.
