Microarray tiles containing DNA sequences for known regulatory elements and novel ones formed two distinct clusters with differing histone modification signatures.
Comparison of translocation of nanoparticles of differing surface modification, effect of siRNA silencing of proteins on nanoparticle uptake, and effect of pretreatment with lung lining liquid was done using one-tailed Mann–Whitney U analysis.
There are over 65 structural variants of microcystins differing in modifications to the peptide backbone or the type of amino acids incorporated into the microcystin [ 1].
Loneliness was defined as a sum score (the sum of 3 items) and the extent to which these scores differed the modification of genetic influences as a function of sex, age and other demographic characteristics was investigated.
Small RNAs loaded into Ago1-RISC and Ago2-RISC differ in modification: small RNAs loaded into Ago1-RISC remain unmodified whereas those loaded into Ago2-RISC undergo 2′- O-methylation at the 3' terminal ribose (Czech et al., Mol Cell, 2009, 36 445-456; Okamura et al., Mol Cell, 2009, 36: 431-444; Ghildiyal et al., RNA, 2010, 16:43-56).
In addition to enantiomers and diastereoisomers, isomers arise through localization variants of post-translational modifications (that is, peptides with identical sequences but differing sites of modification), peptides containing isomeric amino acid residues (e.g., leucine/isoleucine), and sequence inversions in which the order of amino acid residues are altered.
Because phosphatase treatment did not totally eliminate any PGRMC1 spots, it is possible that protein species within these two-dimensional PAGE spots may also differ by modifications other than phosphorylation.
At room temperature the polymer can exist in up to four modifications which comprise one amorphous disordered phase and three more ordered modifications, differing in the interchain organization and in the silicon backbone conformations.
This implies that the degradation was linked to SUMO modification, and that this modification differs between the topoIIα and topoIIβ isoforms [18].
A two-way ANOVA was used to compare the time-dependent uptake of nanoparticles of differing size and surface modification and to compare the effect of temperature on time-dependent uptake.
