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The flexible 1,25(OH)2D3 molecule was found to have a high affinity for both pockets, with differing modes of binding.
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Comparisons among loci with differing modes of inheritance can reveal unexpected aspects of population history.
In other words, C and D embody differing modes of presentation.
Recent analyses of genome-wide E2F binding have indicated that E2F target genes can exhibit non-consensus binding sites, which differ from the consensus sequence, exhibit lower affinity for E2F in vitro, and may be involved in different modes of E2F binding [8], [9].
Van Eps, N. et al. Gi- and Gs-coupled GPCRs show different modes of G-protein binding.
The specific details of the binding mechanism would differ under the different modes of the amino acid-RNA recognition.
Models from the top clusters were very consistent, with all showing similar modes of binding but just differing in the register or orientation of the DNA (Supplementary Figure S3).
A comparison of the RNA-binding properties of the N-terminal and C-terminal ZFa fingers suggested that the modes of binding of ZFa ZF1 3 differed in a qualitative sense from the binding of ZFa ZF4 7 or ZF3 7.
The behaviour of squids and octopuses differs considerably because of their different modes of life.
Finally, detailed analysis of CTCF footprints suggests multiple modes of binding and a novel DNA binding motif upstream of the primary binding site.
In these two forms, the Ligand1 molecule occupied the binding site of Keap1 so as to mimic the ETGE motif of Nrf2, although the mode of binding differed in the two forms.
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