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The differing mode of action and toxicity profile of gemcitabine and marimastat make the combination of these agents an obvious therapeutic strategy to investigate.
The hazard index and the interactions-based hazard index method, described above, are applied for assessing potential health risks due to mixtures of chemicals affecting a given health endpoint by acting with the same or differing mode of action.
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The meta-analysis of anti-angiogenic agents as a group provides a broad answer to the questions posed as it pools both bevacizumab and aflibercept data together in analysis, despite slightly differing modes of action.
If, however, the toxicity profile of an investigational treatment is of particular concern, the activity and toxicity of the treatment may be considered as joint primary outcome measures Emerging cancer treatments have many differing modes of action and this is reflected in the choice of outcome measures.
Rider et al. (2008) found that pre-natal exposure to a mixture of seven phthalates and pesticides with differing modes of action (i.e., AR antagonist or inhibition of androgen synthesis) produced cumulative, dose-additive outcomes in the androgen-dependent tissues.
MELK-T1 could therefore display a different mode of action.
Existing therapies have a different mode of action to eltrombopag.
It is shown that the O.1 test implicitly adopts only one model of inertant action, and that chemicals which rely on a differing mode of inertant action are liable to be incorrectly treated.
There are also different modes of action.
These two compounds have different modes of action [10].
Mutant forms of p53 exhibit different modes of action.
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