Alleles with differing epigenetic marks in the same nucleus do not function in isolation but can interact in trans to modify the epigenetic state of one or both alleles.
This indicates that intra-species epigenomic diversity is modular, with some histone marks differing globally in some strains/individuals, and other marks differing globally in others.
Further experiments, which are beyond the scope of this study, such as chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) in colon tissues to examine the distribution of the H3K27Ac mark, may identify enhancer regulatory sites that differ in mark levels between normal and cancerous samples.
In this work each haplotype is compared against the reference genome and the positions where they differ are marked as '1' and the rest are marked as '0'.
However, a number of differences remain noteworthy: (1) Despite equal GM relative lengths within the overlapping length range, corresponding moments exerted at the ankle differ substantially (marked for reference in Figure 5B).
b,c,d,e Within a column, medians marked with b differ from those marked with c and those marked with d differ from those marked with e (P < 0.05).
Such differing transmission has marked consequences on the epidemiology of malaria in the villages.
For example, genomes of the cyanobacteria Synechococcus sp. from differing habitat types exhibited marked differences, consistent with differences in adaptation to disturbance (Palenik et al. 2006).
In particular, if other active chromatin marks differed between BY and RM at the same loci, then these marks might contribute to the maintenance or re-establishment of H3K14 acetylation differences.
Genomewide scans to identify regions marked by differing gene expression are considered key at this stage.
