The objectives of surgery differed: indications included medial compartment offloading in medial osteoarthritis; a decrease in varus alignment to normal; and a restoration of leg alignment symmetrical to the contralateral leg.
If a drug was approved for more than one indication (e.g. ramipril for hypertension, heart failure, diabetic nephropathy, and others) and conversion factors of different indications differed, this fact was indicated.
An analysis of screening, follow-up and diagnostic patients in relation to total, positive and negative life events showed that total, positive or negative life events did not differ significantly between different indications.
However, we included all indications into our analysis, and subsequent evaluations of the data found that the overhang significantly differs between indications (p = 0.031).
The matching on calendar time permits controlling for trends over time in the use of AEDs and changes in incidence of the outcome, whereas matching on indication of AED is essential to control for the baseline vascular risk that is likely to differ between indications.
There is also a bias in treatment allocation arm according to centers experience and case-volume, surgical indications differing among the studies.
Most likely the opinions of patients differ per indication.
However, they differ in indication, formulation, and presentation (Table 1). 4 Compared with Dukoral, Shanchol offers operational advantages: it does not require administration with a buffer solution, it requires significantly less cold chain volume, it can be administered from 1 year of age (versus 2 years of age), and its price is one-third per dose the price of Dukoral.
Hence, if calcium channel blockers were to be switched, the system did not suggest the substitution of felodipine (indication: hypertension) with nimodipine (indication: prevention of cerebral vasospasm) because of the differing labelled indications.
We sought to determine whether the characteristics of studies supporting drugs' supplemental indications differ substantially from those underlying the indications for which the drugs were originally approved.
