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The second approach to detect differential transcription is based on observing loci in the reference genome at which reads from the two datasets align with different depth of coverage (after appropriate normalization for differing gene expression).
Genomewide scans to identify regions marked by differing gene expression are considered key at this stage.
Microarray analysis has identified breast cancer subtypes with differing gene expression profiles [ 10, 11].
The analysis of transcript data alone showed that germination and seedling development is marked by stages of differing gene expression activity.
Thus differing gene expression among the four arabinose regulated promoters is the result of varying integration of the common signals from the two transcription factors and RNA polymerase.
However, there is experimental evidence of gene expression regulation in Buchnera, since nutritional osmotic stress or organ and embryonic stage specificities are associated with differing gene expression profiles [ 11, 12].
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This study demonstrated differing gene and protein expression profiles of the five CYPs studied in equine intestine and liver.
Fig. 2 also shows the averages for the expression ratio versus fluorescence intensity of the identified 306 genes differing in gene expression (Fig. 2a), together with the corresponding box-plots (Fig. 2b).
A total of 106 genes out of 306 differing in gene expression as concluded from the a priori contrasts were used as probes, and most of them (83%) yielded hybridization signals [see Additional file 3].
Our aim with the present study was to investigate how patients' livers differ in gene expression profile compared to controls and how the differentially expressed genes could affect the disease progress.
Based on the above observations, we sought to further explore whether these modules are functional and whether they differ in gene expression.
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