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It seems unlikely that these differences result only from differing expression levels in the different tissues, because the Ubq promoter appears to drive higher levels of GFP-DSas-6 and DSas-4-GFP in the testes than in the brain.
Fluctuation from the PRC-repressed to the canonical active state (S5p+S7p+S2p+) occurs to variable extents across different PRC targets, resulting in differing expression levels.
Most likely, due to differing expression levels of the two genes in different cell types and tissues, endogenous ABCD2 cannot replace ABCD1 functionally (18, 19).
Because substitutional asymmetries can be assumed to be the decisive causal factor behind compositional asymmetries (Mugal et al. 2009), our results suggest that differing expression levels lead via TIM and TCR to substitutional asymmetries of different strengths and subsequently entail compositional asymmetries.
We also observed differing expression levels of APOE-001 and -002 splice variants in the AD temporal lobe.
Comparisons of MYCN-nonamplified vs MYCN-amplified tumours, localised stages vs stage 4 vs stage 4S and patients below 1 vs above 1 year, did not show significantly differing expression levels.
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Surprisingly, genes differing in expression and genes not differing in expression had the same diversity and frequency of polymorphisms in their proximal promoters.
Two cell populations are distinguished by differing CD16 expression and granulosity (SSC): CD16high and CD16low.
Previous studies have demonstrated several splice variants of NET, differing in expression and function [6].
Obviously, this hypothesis should be tested with a much larger number of lines differing in expression levels.
Genomewide scans to identify regions marked by differing gene expression are considered key at this stage.
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