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This discrepancy may be due to differing experimental protocols: our assays were carried out in different media, in mouse as opposed to rat, and at 37°C as opposed to 35°C, a temperature difference that affects mitochondrial motility (32) and could therefore influence motility responses to DISC1 overexpression.
However, most researchers seem to have considered that these drugs inhibit, rather than stimulate, this enzyme, although differing experimental protocols and crucially, timing, obscure clear interpretation of this issue.
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The contrasts in metrics produced from both studies demonstrate that that correlation structure among metrics can differ significantly under different experimental protocols.
These two studies used different experimental protocols.
All rats were randomly assigned into the different experimental protocols (see experimental protocol section).
Two different experimental protocols were used.
These laboratories may use different experimental protocols.
This is mainly because our data include systematic errors arising from the compilation of data from different laboratories, whose experimental protocols most likely differ.
However, most of them did not provide exact information about the investigated race, and the methods and experimental protocols differed strongly.
In 2007, according to a recent article in Nature, a majority of non-industry-supported studies initially deemed sound by the National Toxicology Program on the safety of BPA were dismissed as unsuitable after a representative of the A.C.C. drafted a memo critiquing their methods; experimental protocols often differ from one university lab to another.
It is likely that these incongruencies relate to differences in the experimental protocols employed since a number of parameters including PGE2 concentration, proliferation time frame and the inclusion/exclusion of serum, among others, differ widely in the referred studies.
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