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Some methods move the operating point from one that optimises separation of events and non-events towards one or the other, depending on the relative misclassification costs [ 24]. "Net Reclassification Improvement", "Weighted Net Reclassification Improvement", and "Relative Utility" all account for differing consequences of correct and incorrect diagnosis [ 24].
As we know at best merely the likelihood of the differing consequences of alternative policies, how should we assess the imposition of differing risks on and the likely or uncertain provision of benefits for future people?.[2] Fourth, is it possible for us to harm past people, and do we have duties toward them?
The differing consequences of impaired Smad signaling in human cancers and the molecular mechanisms that underpin these differences will have important implications for the design and application of novel targeted therapies.
This may reflect the differing consequences of constitutive overexpression of NRG1 compared with the acute effects of exogenous NRG1.
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Adopting either the diachronic or the subjunctive-historical notions of harm excludes the possibility of our harming future people when we choose among long-term policies with significantly differing consequences for the quality of life of future people.
Adopting either the diachronic or the subjunctive-historical notions of harm or both excludes the possibility of our harming future people when we choose among long-term policies with significantly differing consequences for the quality of life of future people.
Our report of deletions and point mutations within the FOX transcription factor gene cluster at 16q24.1 highlights the differing phenotypic consequences of gene alterations in cis.
It may be important to differentiate atelectasis from increased-permeability oedema because of differing therapeutic consequences [ 1, 6, 9, 13- 16].
"Look at the differing scale of consequences".
People will differ on the consequences of this for our 8- to 12-year-olds, to whom the new game is pitched.
To add to the complexity are the differing and unpredictable consequences of each individual viral subtype/strain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com