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The brain tissue was simplified as an isotropic homogeneous material, rather than a site-dependent white and gray matter combination including a dense network of blood vessels, cellular structure, or differing cell types such as glial cells which are highly responsive to brain injury [ 22– 22].
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The choice of polyadenylation site is found to be affected by several factors, such as tissue specificity or differing cell types [13], [33].
This inconsistency may be due to differing cell types used in those studies.
Surely, numerous parameters differ between these cell types such as their membrane composition and permeability, endocytosis rates, and macropinocytosis rates which may, in part, affect total cell uptake [ 31, 32].
In STG neurons, certain pairs of ion channel mRNA transcripts were linearly correlated [6], [12], however the pairs that were correlated differed between different cell types, suggestive that such correlations could be markers of cell identity or activity.
Molecular functions, including those of autophagy related-proteins, sometimes differ according to the organ or cell type, such as somatic versus hematopoietic cells.
Our results predict that CTB diffusion rates will differ in different cell types, with rapid diffusion in GM1-rich cell lines, like Jurkat cells, and slower diffusion in GM1-deficient cell lines, such as T84 and Colo205 cells.
Furthermore, the total p65 abundance differs between different cell types.
Thus, the function of claudin-1 may differ among different cell types.
Similarly, neuromodulators also can modulate synaptic dynamics, in a way that differs across different cell types [29 31].
The demand on autophagy differs among different cell types.
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