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Often, osteosarcoma tissue contains a mixture of morphologically differing cell types, and the classification is based on the most dominant type [ 7].
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Simplistically, we hypothesize that max-2 antagonizes the effect of the Group B Pak, pak-2, but embryonic morphogenesis is a very complex process involving diverse movements of differing cell types (Zhang et al. 2011), and in principle these proteins could even function in separate cells.
Therefore, resulting downstream analysis will be representative of heterogeneous mixtures of differing cell types within these tissues.
This inconsistency may be due to differing cell types used in those studies.
This would not be possible with more complex tissues in which differing cell types are distributed asymmetrically within the specimen.
We propose that the repertoire of proteins targeted by Vpr through this mechanism differs between different cell types, and specifically between T cells and macrophages, thus explaining a more potent effect of Vpr in the latter cells.
Therefore, the relative contribution of these kinases to the effects of Y27632 treatment differ in different cell types and cellular processes.
Glycan structures differ significantly among different cell types and species.
Using multisite neuronal recordings in mPFC, it has been shown that oscillatory responses of cortical cells differ due to different cell types and cortical layers during sleep spindles [ 69].
Mitochondrial mass and function differ significantly across different cell types, and are dynamically regulated by a variety of physiological cues, including physical activity and nutrient availability.
We demonstrate that enhancer activation depends on cis-regulatory motif combinations that differ between cell types and can predict cell-type-specific ecdysone targeting.
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