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It is accepted that the different viral serotypes possess differing affinities for particular cell types, but it is not clear how these properties affect their ability to transduce specific neuronal cell sub-types.
More specifically, sequence differences can result in differing affinities for associated signalling factors or even an association with isoform-specific factors, a possibility we explore in the following section on receptor interactions.
The Glu receptor family contains many members with divergent functions, differing kinetics of activation, differing affinities for Glu, and different sites of localization in regions of the brain or the synaptic region of neurons [ 9].
It has been proposed that ESAG6 sequence polymorphisms allow the trypanosome to express receptors with differing affinities for the polymorphic transferrin molecules from different species of mammalian host [ 27, 28].
Here Nicolas Dauphas shows that elements with differing affinities for metal can be used to decipher the isotopic nature of the Earth's accreting material through time.
Recent crystal structures have suggested two models for the complex between FGFs, FGF receptors (FGFRs) and the proteoglycan heparan sulphate that mediates signalling, and have provided insight into how FGFs show differing affinities for the range of FGFRs.
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This application, most specifically in the imaging of neuro-endocrine tumours (NET), has taken off with the development of 68Ga-DOTA-TOC, 68Ga-DOTA-NOC and 68Ga-DOTA-TATE, all analogues of octreotide with differing affinity for the somatostatin receptor subtypes 2, 3 and 5 [2-5].
However, not all budding yeast tDNAs are capable of barrier activity [47], due to differing affinities of TFIIIB for tDNA upstream sequences, the association of the HMG-like protein Nhp6 [48], as well as the distance between the internal control elements [47].
An alternative explanation is that the biphasic kinetics result from differing affinity of mantATP for the individual motor domains of the MCAK dimer.
NMR and structural analyses of DHFR complexes with inhibitors of differing affinities define a model for ligand dissociation involving conformational switching and a new excited state that mediates the dissociation.
The purpose of this event is to create a space for law students of differing affinities to community build and bond over heartfelt performances, including spoken word poetry.
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