In planta, all stages of differentiation are present in the same tissue, as opposed to the in vitro synchronous cell culture systems where at any given time only TEs of the same differentiation stage are present.
The small round atypical cells without ductal differentiation are present in the majority of the tumor (parts surrounded by solid line).
Unlike deletion of apoptosis genes, genes that mediate cell cycle exit by differentiation are present in myelodysplastic syndrome (MDS) and AML cells but are epigenetically repressed: MDS/AML cells express high levels of key lineage-specifying transcription factors.
Transitional sex chromosomes at an intermediate stage of differentiation are present in D. miranda.
It was demonstrated that cancer stem cells, capable of self-renewal and multilineage differentiation, are present in blood and solid tumors [ 13- 15].
These results not only reinforce the conclusion that the targets of harmine that impact Th differentiation are present throughout the process of differentiation, but also demonstrate that harmine does not impart long-lasting epigenetic signals.
The fact that low levels of H3K23me3 detected during nuclear differentiation are present in micronuclei and not the H3K9me3-enriched developing macronuclei, further defines distinct functions within heterochromatin for these PTMs.
Additionally, comparative genomic analyses show that several other gene orthologs involved in heterocyst differentiation are present in the Trichodesmium IMS101 genome (e.g. hetCF, patB) while others, not unexpectedly, are missing such as those involved in the deposition of the heterocyst outer envelope (e.g. hglCDE, hepB) (Table S1; El-Shehawy et al., 2003; Larsson et al., 2011).
Criteria that can be used to make this differentiation are presented in detail and discussed.
Postoperative histopathological findings (TRG, UICC classification and tumour differentiation) are presented in Table 1.
