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Moreover, the standardized uptake values of carcinosarcoma are higher than those of squamous cell carcinoma regardless of differentiation type because the sarcomatous element of carcinosarcoma shows higher FDG uptake than the carcinomatous element [27, 28].
bHistological differentiation: good, moderate and poor tumor differentiation type.
Especially disconcerting is the observed selection with respect to the differentiation type.
For example, the average proportions of short- versus long-range connections for areas of the highest cytoarchitectonic differentiation (type 5) were 65%and9% 9 %, respectively, compared to 45%and25%25 % for those of the lowest differentiation (type 1).
Therefore, we could not ascribe these surface marker alterations to an activation or a known differentiation type.
Consequently, the randomised patients may not be representative for all eligible patients with respect to differentiation type.
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We continued to examine the HOXB9 expression profile in three typical differentiation types of colon adenocarcinoma that include well-, moderate- and poorly differentiated tumours.
Colonies were counted after 14 days according to featured differentiation types and images were collected with a Leica DMIRB microscope.
It can act synergistically with growth factors to upregulate the expression of SOX9 (a key chondrogenic transcription factor) and the synthesis of cartilage-specific matrix molecules (proteoglycans, type-II collagen) while downregulating the expression of genes associated with terminal differentiation (type-X collagen) (Vinardell et al. 2012).
In fact, signs of hypertrophy have been documented with MSC chondrogenic differentiation: type-X collagen, MMP13, alkaline phosphatase (ALP) are signs of terminal differentiation that may lead to mineralization in vivo and thus to the formation of a low quality cartilage (Hellingman et al. 2012).
We were also interested in association between differentiation types, metastasis and surgery status of GC and COX-2 methylation levels.
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