Sentence examples for differentiation trajectory from inspiring English sources

Furthermore, delineation of their differentiation trajectory was achieved by a machine learning method.

Here the authors define, using multi-color lineage tracing and single-cell transcriptome analysis, the subset distribution and differentiation trajectory of fibroblastic reticular cells to serve structural insights for splenic white pulps.

As expected, 24 h after purification, the majority of the mCherrylow cells became mCherryhigh and FLK1/PDGFRα DN, pursuing their normal hematopoietic differentiation trajectory (Fig. 3i, Supplementary Fig. 3g).

Aggregation phenomena are central to such bioprocesses affecting the viability, proliferation and differentiation trajectory of stem cells but a quantitative framework is currently lacking.

We observe heterogeneity within common myeloid progenitors (CMPs) and granulocyte-macrophage progenitors (GMPs) and develop a strategy to partition GMPs along their differentiation trajectory.

For example, cells with a gain of chromosome 20q11.1-11.2 had a significantly reduced propensity to differentiate down the hematopoietic lineage and in the neural differentiation experiments the variant cells displayed more immature phenotypes along the differentiation trajectory than their wild-type controls (Werbowetski-Ogilvie et al., 2009).

We performed dimension reduction using the DDRTree method in Monocle 218, and then used SLICE19 to predict cell differentiation states and differentiation trajectories (Supplementary Figures 8 and 9).

We collected single-cell chromatin accessibility profiles across 10 populations of immunophenotypically defined human hematopoietic cell types and constructed a chromatin accessibility landscape of human hematopoiesis to characterize differentiation trajectories.

The SCS technologies can help to define new classifications and differentiation trajectories of immune cells.

Analysis of the differentiation trajectories of the parent and daughter clones uncovered a new hierarchical schema for MSC self-renewal and differentiation.

The distinct differentiation trajectories observed under these two conditions illustrate the potential for manipulation of output cell populations by controlling the input population and/or the presence of exogenous factors and interactions during hEB-mediated differentiation.