Taken together, these data suggest that modulation of Btk levels can differentially affect B-cell differentiation, survival, and function without eliminating the majority of mature B-cells.
Next to its anti-inflammatory capacities, IL-10 promotes the differentiation, survival, and activity of B cells.
Their activation can lead to lymphokine production, cytolitic activity, antibody secretion, cell proliferation, differentiation, survival and phagocytosis.
To directly study how BM proteins influence epidermal differentiation, survival and growth, we developed novel 3D human skin equivalents (HSEs).
The 22 members of the fibroblast growth factor (FGF) family have been implicated in cell proliferation, differentiation, survival, and migration.
RANK is a membrane receptor on osteoclasts and immune system cells, and binding with RANKL is necessary to promote differentiation, survival and activation of osteoclastic cells.
JNK activation induces phosphorylation of c-Jun and other downstream molecules, which in turn regulate expression of genes involved in cell growth, differentiation, survival, and apoptosis.
The dynamic interplay between ECM and resident cells exerts its critical role in many aspects of wound healing, including cell proliferation, migration, differentiation, survival, matrix degradation and biosynthesis.
The EGFR family tyrosine kinase receptor is a cell surface receptor that regulates diverse biological processes including cell proliferation, differentiation, survival, and apoptosis.
IL-15 is the major physiologic growth factor responsible for NK cell differentiation, survival and cytolytic activity of mature NK cells.
Besides these receptors, other factors that are directly or indirectly responsible for differentiation, survival, and activity of osteoclasts are cytokines (IL-1β, TNFα, IL-6) and chemokines (CCL2, CCL3, CCL5, CCL7, CCL9, IL-8) [68],[69].
