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We also use some historical evidence to calibrate differentiation speed and give estimates of time since separation for the different cases studied.
Thus, depending on external conditions, ecdysteroid signaling regulates the early germline differentiation speed via miRNA let-7 expression induction.
These stimulate ISCs to respond to increase their division rate and differentiation speed (Buchon et al, 2009a, b; Jiang et al, 2009, 2011).
Together, orchestrated regulation of oogenesis executed by insulin and ecdysone hormones reassures that the germline differentiation speed is perfectly attuned to external and internal cues.
The role for the Wg pathway in the Drosophila germline has not been reported previously, our data show that the Wg signaling intensity positively affects the early germline differentiation speed.
Therefore, we propose that upon stress and ecdysone deficit, Ab acts as a regulator of gene expression to adjust function and form of epithelial cells of the germarium, which cell non-autonomously affects the germline differentiation speed.
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Initially, settlement was sparse, as is always the case with hunting cultures, but language differentiation sped up with the change to sedentary agriculture.
As explained by Sarkar et al., these epigenetic changes are grade-specific and variable because they occur at different times, when growth slows down and differentiation speeds up.
Allowing the body to direct differentiation could speed the U.S. Food and Drug Administration's approval of using such pluripotent stem cells, Longaker believes, by eliminating the extended periods of laboratory manipulation required during the forced differentiation of the cells.
Zook and Allen show how some of the world's best-known firms combine a core differentiation model with speed, adaptability, and simplicity to land them at the top for long periods of time.
In addition, further questions in the field will be pondered, including the phenotypic and functional overlap between pericytes and culture-derived MSC, and the concept of pericytes as efficient producers of differentiation factors to speed tissue repair.
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