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To identify the possible biological characteristics of osteosarcoma, a comparison of osteosarcoma expression profiles with profiles from their presumed progenitors, that is, MSCs and osteoblasts derived from these MSCs by in vitro differentiation, resulted in a large set of 2973 differentially expressed genes.
Subsequent differentiation resulted in generation of mature 3D networks of neurons (MAP2+) and glia (S100beta+) cells.
However, in vitro differentiation resulted in the loss of GFP expression in 50% of cells.
Malignant regression of cancer cells by in vitro differentiation resulted in partial reversion of LRES and gain of CTCF binding.
ESC differentiation resulted in repression of OCT4 expression in both the absence and presence of aza-dC treatment.
These mCherry+ NPCs could be expanded in culture and their differentiation resulted in a down-regulation of mCherry consistent with the loss of Nestin expression.
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In the cytotrophoblast, proliferation is restricted to a small subset of progenitor cells, which divide asymmetrically and undergo differentiation resulting in fusion with the overlying syncytium13, 14.
However, CB-derived cells exhibited a delayed kinetics of differentiation, resulting in an increased number of progenitors, notably colony-forming unit (CFU-E).
Aging tilts the balance in favor of adipocyte differentiation at the expense of osteoblast differentiation, resulting in reduced bone formation and osteopenic disorders, including osteoporosis, in humans and animals.
The rice cultivars differed significantly in aerenchyma tissue differentiation resulting in different degrees of aerobic conditions in their rhizosphere.
Conversely, Yap overexpression increases stem cell self-renewal and blocks terminal differentiation, resulting in epithelial hyperplasia and stratification.
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