Differentiation is responsible for the specialization of cell types, growth for increasing the cell population and morphogenesis ("beginning of shape") is responsible for the spatial and temporal organization that gives an organism its complex three-dimensional structure.
The cell-type specific organization of heterochromatin, established upon cell differentiation, is responsible for maintaining much of the genome in a repressed state, within a highly compartmentalized nucleus.
Identifying the perturbations in signaling pathways and cellular differentiation programs responsible for tissue damage and fibrosis in SSc allows their selective targeting using novel compounds, or by innovative uses of already-approved drugs (drug repurposing).
Since the lower proliferative index we observed in rapamycin-treated KC PTEN tumours coincided with histological change, we wanted to investigate whether changes in differentiation were responsible for the decrease in proliferation.
Keratin patterns were normalized; that is, basal cells expressed keratin K5/14 and cells in the layers above keratin K1/10, followed by late differentiation markers, responsible for epidermal barrier function.
Although numerous studies have now reported a role for GALT-DC in promoting mucosal lymphocyte differentiation, the factors responsible for imparting DC with this function remain largely unknown.
This coordinated developmental process of chondrocyte proliferation and differentiation is ultimately responsible for longitudinal bone growth and the final length of mature bone.
In order to understand the evolution of social insects, it is important to elucidate the proximate mechanisms of behavioral differentiation that are responsible for the development of elaborate social behavior [1], [15], [25].
Do the authors suggest this implies that differentiation is mainly responsible for the patterning effects?
Blockade of DCs at an early stage in differentiation could be responsible for this inconsistency between patients.
