Sentence examples for differentiation regulatory from inspiring English sources

Unraveling intra- and inter-cellular signaling networks managing cell-fate control, coordinating complex differentiation regulatory circuits and shaping tissues and organs in living systems remain major challenges in the post-genomic era.

Consistent with this notion, mutant mice lacking myosin heavy chain IIA gene demonstrated embryonic lethality due to early differentiation and cell adhesion defects [59] further indicating the potential significance of myosin II in differentiation regulatory processes besides cell adhesion.

Cell lines established from tracheobronchial epithelial cells expressing SV 40 large T-antigen, as well as carcinoma cell lines, exhibit altered responses to growth and differentiation regulatory factors.

In terms of what are the actual intracellular effects of P. gingivalis in osteoblasts/osteoclasts, our previous in vitro study demonstrates that invasion of P. gingivalis does not affect osteoblast proliferation, but inhibits their differentiation and mineralization, partially via an inhibition of the differentiation regulatory transcription factors Cbfa-1 and osterix [ 15].

Here, we report an atlas of differentially expressed genes during epidermal differentiation and regulatory regions that are bound by p63, a key regulator in epidermal differentiation.

The PGE2-specific inhibitor NS398, but not the iNOS inhibitor L-NMMA, significantly blocked the differentiation of regulatory DCs from DC precursors as well as the suppressive function of regulatory DCs (Fig. 6C,D).

To further explore the molecular mechanisms involved in differentiation of regulatory DCs, we assayed phosphorylation of PI3K and ERK1/2 as activation indicator in MSC-induced regulatory DCs.

Simulations showed that the landscape topology determines the propensity of differentiation and regulatory complexity.

Those dendritic cells present antigen to T cells in mesenteric lymph nodes, which leads to differentiation of regulatory (Treg) and anti-inflammatory (Th2) T cell populations, mediated by transforming growth factor beta (TGFß), IL-4, IL-10, and IL-13.

These TRAs represent a pool of self-antigens, which are used to negatively select auto-reactive thymocytes to induce self-tolerance or differentiation of regulatory T cell subsets.

Evidence demonstrates a fundamental role for monocytes in activation of NK cells [23] and in differentiation of regulatory T cells [24] upon P. falciparum stimulation in vitro.