Exact(8)
The zinc finger transcription factor KROX20 is a key regulator of Schwann cell differentiation, regulating both cell cycle exit and the gene expression that drives myelination (Topilko et al., 1994; Zorick et al., 1999; Parkinson et al., 2004, 2008).
RA and its metabolites also play a crucial role in adult physiological functions such as promoting growth and differentiation, regulating apoptosis, and maintaining homeostasis in numerous tissues [27].
In rodent skeletal muscle, STAT3 is essential for satellite cell migration and myogenic differentiation, regulating the expression of myogenic factors.
Thus, tsh plays a decisive role in SC differentiation, regulating the expression of terminal genes that are crucial for their physiological role.
ROS is involved in signalling cell growth and differentiation, regulating the activity of enzymes, mediating inflammation by stimulating cytokine production, and eliminating pathogens and foreign particles [ 43].
For both cell populations, activation of MEK-ERK1/2 pathway by thrombopoietin was found to have a critical role in MK differentiation, regulating polyploidy and surface expression of CD34, GPIIb, and GPIb.
Similar(52)
The absence of transcriptionnal regulation of DNA-PKcs suggests that adipogenic differentiation regulates either DNA-PKcs protein biosynthesis or degradation.
However, the precise mechanism of neuronal differentiation regulated by TET1 should be further investigated.
Recently, it has been shown that disruption of the fly orthologue of HD-PTP resulted in a defect in photoreceptor differentiation regulated by EGFR [4], [12].
Neuregulins for example promote neuronal migration and differentiation, regulate the expression of neurotransmitter receptors, influence glial proliferation, survival and differentiation and play a role in synaptic plasticity.
In the brain, PCBs may disrupt normal differentiation regulated by thyroid hormones, although they do not act as thyroid hormone-like ligands (Zoeller 2005).
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