Therefore, increased miR-3099 expression during P19 differentiation raises the possibility that this miRNA may have a functional role during neural differentiation or neuronal cell function.
Mafb's potent effects on the late stages of SGN differentiation raise the intriguing possibility that Mafb may serve as a terminal selector in the vertebrate nervous system.
Induced pluripotent stem cells (iPSCs) resemble embryonic stem cells (ESCs) in morphology, gene expression and in vitro differentiation, raising new hope for personalized clinical therapy.
Several of the EtoL regions recapitulated developmental changes that occur during ES cell differentiation, raising the possibility that the observed changes might be an indirect result of cell differentiation after BAF250a loss.
Recently, homotypic interaction of CD27 and CD70 expressed by B cells was also reported to be sufficient for B-cell differentiation, raising the possibility that B cells may be able to regulate themselves by CD27 CD70 interactions [ 72].
Our finding that c-Myc-regulated miRNAs miR-141, miR-200, miR-338, and miR-429 are expressed in ES cells and that a subset of their target genes is associated with lineage differentiation raises the question of whether these miRNAs affect the balance of ES self-renewal and differentiation.
Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%.
»Isolation and cultivation of pancreas stem cells as renewable sources of beta cells would be a major breakthrough…« The discovery of stem cells which have virtually unlimited self-renewal and multi-differentiation potential raised great expectations for their use in regenerative medicine.
These findings reveal a new function for Tim in the coordination of ES cell differentiation, and raise the intriguing possibility that circadian rhythms and early development may be intimately linked.
Taken together, the results demonstrate that disabling the expression of either Ret or TrkB causes a failure in RA-dependent cell differentiation, thus raising the question of the existence of a cooperative cross-talk between TrkB and Ret in neuroblastoma cells.
