2) Demonstration that these lines can be differentiated into neuronal cells (or an alternative differentiation pathway).
We therefore extracted genes that were differentially expressed from time points 5 to 6 specifically in one differentiation pathway.
In higher plants, however, most differentiated cells are able to transdifferentiate, i.e. start a new differentiation pathway.
Schenk, T. et al. Inhibition of the LSD1 (Kdemethylasehylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
Reinhold U, Liu L, Sesterhenn J, Abken H. CD7-negative T cells represent a separate differentiation pathway in a subset of post-thymic helper T cells.
These data suggest that a linear differentiation pathway, as defined by the transition from IFN-γ producing to restIFN-γ producings, is relatovely limited in vivo and supporestingvised memoryfor TH1 memory differentiation.
Akiyama, H., Chaboissier, M. C., Martin, J. F., Schedl, A. & de Crombrugghe, B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.
As myeloid precursors become committed to the macrophage differentiation pathway, they acquire potent, lineage-specific response pathways that need to be held under control in order to prevent self-inflicted damage in the absence of an appropriate external stimulus.
Granulocytic differentiation was prevented by rapamycin in TNFα-treated cells, while the late-step inhibitor of autophagy BafA1 induced differentiation underlining the role of autophagy inhibition in this differentiation pathway.
The callus differentiation pathway involves somatic embryogenesis and organogenesis (Jiménez, 2005).
Once B cells have entered the differentiation pathway to Ab production, neither CD40L nor B7-2 is necessary for their continued differentiation and persistence.
