Sentence examples for differentiation of plasma from inspiring English sources
Blimp-1 is required for the differentiation of plasma cells as well as for the maintenance of T-cell function and homeostasis28,44,45,46,47,48.
TNFRSF17 encodes the receptor for the B-cell growth factor BLyS-BAFF known to play a key role in the differentiation of plasma cells (Vincent et al. 2013).
Notwithstanding, principal component analysis revealed that lactate was a strong contributor to differentiation of plasma from insulin treated and insulin deprived type 1 diabetic individuals.
SLE is an autoimmune disease characterized by the differentiation of plasma cells that secrete pathogenic autoantibodies [ 15].
In addition, the observation that pDCs directly induce the differentiation of plasma cells into immunoglobulin-secreting plasma cells suggests that pDCs are critically involved in humoral responses [ 13, 14].
A hierarchical organization of clonally related MPCs was furtherly demonstrated by studying the expression of XBP-1, a transcription factor important for the differentiation of plasma blasts into plasma cells.
IL-6 signaling is known to be critical to the growth and differentiation of normal plasma cells as well as PCT and MM.
Notably, the p38 MAPK regulates the production of a number of cytokines, including IL6 [ 23] that promotes differentiation and survival of plasma cells [ 24- 27].
In our study, we measured IL-6, IL-10, and HGF, three factors important for differentiation and/or proliferation of plasma cells.
IL-6 is required for the differentiation and maintenance of plasma cells in the bone marrow (discussed above) and is also required for the growth and survival of myeloma cells.
Gatto, D. et al. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1.
