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These results suggest that Fezl regulates the differentiation of layer 5 subcortical projection neurons.
Its initial expression in the intermediate zone and cortical plate is correlated with the early migration and differentiation of layer 5 neurons.
Ctip1 critically regulates differentiation of layer IV neurons, and selective loss of Ctip1 in cortex deprives thalamocortical axons of their receptive "sensory field" in layer IV, which normally provides a tangentially and radially defined compartment of dedicated synaptic territory.
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Interestingly, we noticed the presence of such a group of transcription factors that control the differentiation of layer-specific properties of cortical projection neurons in our NEUROD2 target gene dataset.
Additionally, we show that differences in the morphology are accompanied by substantial differentiation of the layer nanohardness.
This expression is conserved in nonmammalian vertebrates where Oct4 homologs prevent premature differentiation of germ layer progenitors [ 9 12].
The RECEPTOR-LIKE PROTEIN KINASE2 promotes the periclinal division and differentiation of middle layer cells from inner secondary parietal cells (Mizuno et al. 2007).
Prominently, we verify that expression of Cdk5r1, a critical regulator of radial migration, and Cux1, a transcription factor which controls the differentiation of upper layer (II/III and IV) projection neurons [ 52– 54] is dependent on NEUROD2.
The majority of the most profound developmental events – the establishment of the body axes, the differentiation of germ layers, and the appearance of organs and structures – occur with remarkable speed: within the first 2 months of life in humans, and much faster in the animal models that we typically use to study development.
In a similar way, the analysis of the role strategic consistency is playing in organizational learning offers us a deeper insight into how acquirers develop and adapt competencies to execute individual acquisitions as well as to manage acquisition series (see Laamanen and Keil 2008 for a differentiation of different layers of acquisition capability development).
In the present study, LM was applied to dissect endosperm tissues at the early storage phase, 7 DAF, when the differentiation of aleurone layers and starchy endosperm is already distinct (Ishimaru et al. 2003) and the degree of starch accumulation varies with endosperm region (Hoshikawa 1968).
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