0 stands for unity, for a void undifferentiated in space and time. 1 stands for an initial act of differentiation: the division of light from darkness, for example, or of black from white, male from female, nature from culture, left from right.
The resolution of the above conundrum is suggested to be that elevated expression of CEA/CEACAM6 in colonocytes prior to their differentiation and loss of division potential is required for the manifestation of their tumorigenic effects.
Unlike mammalian tissue culture and nervous tissue, nucleolar CTCF did not require terminal differentiation and cessation of division in Drosophila since we observed CTCF in the nucleoli of undifferentiated cycling interphase S2 tissue culture and larval neuroblast cells (Figures 1C, D).
Nodule organogenesis involves the altered differentiation and division of root cortical cells prior to the formation of the nodule primordia.
Indeed, the rigid timescale of differentiation and division is the key for generating staging patterns because a wide range of differentiation and division time creates asynchronous cohorts of germ cells and disrupts stages.
Rossetti, V., Schirrmeister, B. E., Bernasconi, M. V. & Bagheri, H. C. The evolutionary path to terminal differentiation and division of labor in cyanobacteria.
SPOROCYTELESS (SPL /NOZZLE (NZZ) encodes a protein related to MADS box transcription factors and is required for cell differentiation and division of anther cell walls in Arabidopsis [ 26– 29].
The protein expressed by Foxo is a transcription factor that is thought to play a major role in caste differentiation and division of labor by regulating insulin signaling [ 78, 79].
The monogenic fleshless berry (flb) mutation in Vitis vinifera L. cv Ugni Blanc early after fertilization impairs the differentiation and division of the most vacuolated cells in the inner mesocarp that forms the flesh, resulting in a 10-fold reduction in fruit weight [ 23].
We tested all parameters and found that variations in each of six parameters – initial number and division of spermatogonial stem cell, differentiation time, division time, and lifespan of differentiating spermatogonium, and differentiation time of preleptotene – stop the transition to differentiating spermatogonia leading to the VAD phenotype (supplementary material Table S3).
