Coordinated changes in gene expression underlie the transition from a pluripotent stem cell state through lineage commitment and differentiation into a vast array of cell types.
Our data support previous observations that glioblastoma represents a neoplasm capable of a vast phenotypic diversity in differentiation patterns [ 1, 3, 16].
It has been shown over the past two decades to be a critical regulator of a vast array of biological processes, including development, cell proliferation and differentiation, DNA repair, and apoptosis.
Hardly any of these genes would change in expression over the next two weeks of differentiation, as the vast majority of genes that show change in expression during the first three weeks do so during the first week in this differentiation system.
Despite these caveats, the last decade of research has seen a vast improvement in neuronal differentiation of human pluripotent stem cells.
As2O3 acts on cells through a variety of mechanisms, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects that include apoptosis induction, growth inhibition, promotion or inhibition of differentiation, and angiogenesis inhibition [ 23, 24].
However, a vast body of conflicting literature is available describing the attachment, proliferation and osteogenic differentiation of osteo-progenitor cells grown on chitosan membranes with different degrees of deacetylation [ 23].
In the Ecdysozoa, a vast variety of ontogenetic programs lead to the specification of the endoderm and its differentiation into a functional gut, mostly influenced by the particular ecological and developmental adaptations of each organism.
They are involved in a vast array of diverse physiological functions such as the control of embryonic development, the regulation of cell differentiation, and the maintenance of homeostasis.
