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The precise role of LAMP proteins during MbCD-induced muscle differentiation needs to be further investigated.
Therefore, the exact role of miR-663 at different stages of the neuronal differentiation needs to be explored in future studies.
3) The evidence for the conclusion that NF-κB signaling in pancreatic progenitor cells regulate endocrine differentiation needs to be strengthened.
Whether GADD45β is an upstream modulator of C/EBPβ in this instability-induced OA in mice, as was shown in chondrocyte terminal differentiation, needs to be shown in future experiments.
Even though it was presented above that significantly more TRAP+ multinucleated cells can be obtained from the PM population, actual osteoclast differentiation needs to be confirmed as osteoclasts and macrophage polykaryons are morphologically similar [ 29]; in addition, TRAP staining does not distinguish very well between such populations in the human.
The role of decorin in decellularized ECM on cell proliferation and differentiation needs to be elucidated in future.
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Furthermore, the optimal dose of rhOP-1 on cell differentiation still needs to be elucidated.
ATRA treatment up-regulates LRRC25 expression in APL blasts, whether it could be a response marker for ATRA-based differentiation therapy needs to be further studied.
The reason for the variation of induction across osteoblast differentiation also needs to be determined.
Practically the only conclusion is that a new not understood phenomenon is at hand with respect to transcription during aging and differentiation that needs to be studied.
The results of this study are independent of glycemic control but nevertheless the functional meaning of an improved EPC differentiation still needs to be clarified.
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