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Interestingly, for the most differentiated gene, Tas2R9 (FST = 0.41), the NJ tree (Additional file 5) does suggest the presence of introgression in Large White and Hampshire, as well as in some Creole pigs, Assuming that the genome wide pattern is primarily the result of drift, a less than expected differentiation might be explained by some sort of balancing selection at the TR genes.
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Aside from differentiation, lower expression of these surface markers might be explained by the influence of the tumour microenvironment.
This fact might be explained due to the enhancement of osteoclast differentiation by the adjustment of RANKL [ 68].
Oct4 has been proposed to be important for promoting mesendodermal differentiation (Thomson et al., 2011) and part of this mechanism might be explained by switching binding partners from Sox2 to Sox17 (Aksoy et al., 2013).
The observed lack of LOX-1 expression on IFNα (as well as IL-4) MoDC as compared to earlier studies might be explained by the IFN α-subunit and/or source used for differentiation.
This might be explained by several factors.
Although this limited response might be explained in part by poor antigenicity, BC and PDAC are also known to expand systemic populations of immune-suppressive myeloid cells by increasing differentiation from myeloid progenitors in the BM7,8,44.
This might be explained by several reasons.
This might be explained by saturated growth.
This might be explained by the surgical procedure itself.
This positive effect might be explained by its chemical composition.
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