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Additional mutations in cancer stem cells that alter molecular pathways influencing genome stability, resistance to apoptosis, and normal growth and differentiation, may occur during tumorigenesis, leading to substantial genetic and functional diversity among clonal populations of cells within a primary carcinoma [29, 30].
Our data suggest that morphological differentiation may occur rapidly in Polygonia, once speciation has occurred.
Indeed, our data indicate that germ cell differentiation may occur more spontaneously in iPSCs than in hESCs.
This indicates that promoter methylation of specific genes involved in cellular differentiation may occur and thereby commit cells towards a specific lineage.
In population genetics, a gene flow lower than 1 (Nm < 1) is generally regarded as the threshold quantity, below which significant population differentiation may occur (Slatkin 1987).
Alternatively, if I. nautilei disperse in a manner consistent with other sessile invertebrates with specialized habitat needs [ 41] genetic differentiation may occur at spatial scales less than one kilometre.
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A similar de-differentiation process may occur during the formation of germ cell teratomas during embryogenesis [9].
Additional work is thus needed to discriminate the growth and differentiation potential that may occur outside normal tissue homeostasis from lineage differentiation that occurs in normal homeostasis.
Work is ongoing to test whether the therapeutic effects noted in vitro here, including those on hypertrophy and terminal differentiation, may also occur in relevant, orthotopic experimental models in vivo with native mechanical environment (Madry et al. 2013).
Impaired TFH-cell differentiation may well occur when OX40 is ligated upon re-exposure to antigen, where 2W1S-specific CD4+ T cells rapidly up-regulate OX40 regardless of their effector or TFH-cell phenotype.
Behavioral differentiation among termite castes may occur through such neuronal modifications.
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