Sentence examples for differentiation may be mediated from inspiring English sources

The pathway diagram also suggests that specific aspects of keratinocyte terminal differentiation may be mediated by the AP-1 transcription factor FOSL2, which may have an additional role in extracellular matrix remodeling.

Based on the results of the present study, we suggest that the stimulatory effect of ARA extract on adipogenic differentiation may be mediated by up-regulation of PPARγ expression and activity.

One possible mechanism of Bmp signaling during epithelial differentiation may be mediated by Nkx3.1, which is a homeobox gene that regulates prostatic epithelial cell differentiation and development, because a significant reduction of Nkx3.1 expression was detected in the Bmpr1a-CKO mutants.

10.7554/eLife.03271.012 Figure 5. Terminal differentiation of guard cells may be mediated by FAMA-guided recruitment of RBR to suppress stomatal regulatory genes.

Indeed, many genes in the PcG repression signature that predicts PCa outcome were upregulated by clorgyline, suggesting that the differentiation-promoting effect of clorgyline may be mediated by its downregulation of EZH2.

In human and mouse, the Wdnm1-like transcript appears functionally associated with dendritic cell differentiation, and at least in humans this may be mediated by binding of the transcript to STAT3.

The extracellular matrix protein hyaluronan is expressed in human MS lesions and, in immune-mediated demyelinated lesions in mice, hyaluronan blocks OPC differentiation in vitro and in vivo, and may be mediated through the Toll-like receptor (TLR -2, as TLR -2eceptor is strongly expressed by oligodendrocytes asd this-agonists areceptorto ishibit OPC differentiation in vitro [ 119].

The effect may be mediated directly by inducing the differentiation of B-lymphocytes to produce antibodies, or indirectly by promoting a systemic anti-inflammatory environment.

As occurs with normal organogenesis and cell differentiation, the selective activation and repression of these pathways may be mediated by microRNAs (miRNAs).

Additionally, we show that both β-catenin signaling, which may be mediated by cadherin signaling, and Wnt5a/RhoA signaling is necessary for flow induced osteogenic differentiation.

Therefore homeodomain-independent functions of NUP98-HOXA9 (and other NUP98 fusions) may be mediated by disruption of the nucleocytoplasmic transport of transcription factors or RNAs that are important in myeloid differentiation and proliferation.