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As we studied, there was some differentiation in the mechanical strength of the surface and interior of the treated samples manifesting with different contact angle and color (Figure 7).
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Because our preliminary experiments demonstrated that not only mechanical stress but also BMP-2 stimulate IL-11 expression in osteoblastic cells (Figure S1), there is a possibility that BR-Smad signaling is also involved in the enhancement of osteoblast differentiation in response to mechanical stress.
These studies demonstrate that changes in the mechanical properties of cartilage during OA may favor the differentiation of MSCs towards nonchondrocytic lineages further intensifying the degeneration of cartilage.
The Sertoli cells play an important role in the mechanical movement of germ cells from the basal to the adluminal side during their differentiation [ 12].
This raises an interesting possibility of YAP/TAZ in mediating MSC differentiation in response to mechanical stress.
The Rho/ROCK pathway has been suggested to play a role in the differentiation of MSCs into several connective tissue lineages, such as into bone or adipose tissue, and also in tenogenic differentiation in response to mechanical stretch.
Alternatively, changes in the mechanical forces in these altered hearts might result in a different microenvironment for the cardiomyocytes inducing a re-differentiation or de-differentiation process in these cells (Porter and Turner, 2009; Schenke-Layland et al., 2008).
Mechanical stimuli are one of the factors that affect cell proliferation and differentiation in the process of bone tissue regeneration.
It also helps address differentiation in the classroom and encourages teachers to take risks.
But, he added, "going forward, we're going to see some marked differentiation in the strategies".
Sex determination and sexual differentiation in the avian model, FEBS Journal, 278 (7) 1027-1034.
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