The company's strategy, which had historically emphasized cost leadership, needed to shift toward greater service differentiation in response.
Interestingly, changes in the bacterial flagellar motor activity lead to cell differentiation in response to changes in environments40.
Such studies include analyses of the epigenetic changes in chromatin that occur during differentiation in response to retinoids.
Seiler, M.P. et al. Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.
Kindlin-2 controls mesenchymal stem cell differentiation in response to matrix stiffness by regulating the levels and activity of YAP and TAZ.
Muscle progenitor cells migrate from the lateral somites into the developing limb, where they undergo patterning and differentiation in response to local signals.
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.
VIC differentiation in response to exogenously delivered transforming growth factor-beta1 (TGF-β1) was also examined within the hydrogel networks.
Hallowell RW, Collins SL, Craig JM, Zhang Y, Oh M, Illei PB, Chan-Li Y, Vigeland CL, Mitzner W, Scott AL, Powell JD, Horton MR. mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis.
Building the appropriate microenvironment for cell differentiation in response to exogenous stimuli is a critical step towards the clinical utilization of hMSCs.
Conditional deletion of the tyrosine phosphatase Shp2 in mouse myeloid cells increased remodeling/profibrotic (M2) macrophage differentiation in response to IL-4 resulting in decreased susceptibility to pulmonary fibrosis [237].
