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Mature red blood cells lack a nucleus making their terminal differentiation highly dependent on post-transcriptional control; this can be modelled by dimethylsulfoxide treatment of MEL (lymphoma-derived murine erythroleukaemia) cells.
A signature of this network is a pervasive redundancy that made the circuitry challenging to unravel experimentally, but renders GSC decisions (self-renewal versus differentiation) highly robust and regulatable [ 9, 10].
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The degree of PSG9 expression in the tumour samples appears to be related to differentiation, with highly differentiated cells expressing the highest levels.
Laminin-5 γ2 expression was associated with the degree of cancer differentiation, being highly expressed in moderately differentiated and poorly differentiated carcinomas (P = 0.004) (Table 1).
Based on these results we postulate that precise temporal regulation of the Notch signalling cascade is an integral part of NB cell differentiation from highly proliferative neuroblasts into terminally differentiated neuronal cells.
Because tissue differentiation is highly dependent on cell density [ 70], we attempted to recapitulate this developmental process with long term culture of highly cellular HCS tensioned as TSB.
In cross-section the differentiation is highly interpretative, but the 3D bathymetric expression is unequivocal.
Stem cells are characterized by their ability for unlimited or prolonged self-renewal and differentiation into highly distinct cell lineages.
The localized nature of this technique allows clear differentiation between highly conductive amorphous regions and less conductive crystalline regions of the film.
The way designers deal with emotions could be an important source of differentiation in highly competitive markets like the car industry.
These cellular functions, which include heightened resistance of muscle progenitor cells to apoptosis, migration to site of injury, and prevention of premature differentiation are highly desirable in the healing cascade after acute muscle trauma.
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