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Genes in the vicinity of these regulatory regions showed increased expression levels, while genes that were activated during differentiation gained Pol2 at close enhancers [ 56].
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The second one is given in Brunovski form in which the output to be differentiated appears as a control input and the differentiation gain is calculated from the dual Lyapunov equation of the first differentiation observer.
The information on tumour stage and grade of tumour differentiation was gained from pathology reports.
As ENCODE data of NHEKs were collected at only one condition and provide limited information for the transcription program during epidermal differentiation, we further investigated the H3K27ac occupancy at all four stages during epidermal differentiation to gain insight into the activity dynamics of the p63-bound regions.
Although the authors cannot perform live imaging with eye discs they use the stereotypic sequence of photoreceptor and cone cell differentiation to gain temporal information on how Yan expression changes during the transition from multipotency to the differentiated state.
NGN3+ cells might be more appropriately considered as stem cells that have gained differentiation competence, rather than as transit-amplifying cells that possess de-differentiation ability.
Insight into the accretion of the Earth and its subsequent differentiation can be gained through knowledge of the present-day Earth composition.
Illustrating the key advantage of AGEP method in context-specific comparisons, we were able to identify that during the stem cell differentiation cells also gained similarity with cardiomyocytes.
The goal of gene expression profiling in the early phase of Th17 differentiation is to gain insight into the process of differentiation by unraveling dependencies between key factors and to understand how the differentiation signal propagates through various pathways and gene regulatory networks.
In this study, upon ES differentiation, the Ucp1 enhancer gained methylation, and genistein treatment rather amplified this increase in methylation levels (Figure S9).
It is unclear whether the in vivo multi-lineage differentiation capacity can be gained following the progression from low-grade to high-grade gliomas.
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