Sentence examples for differentiation determinant from inspiring English sources
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
Thank you for sending your work entitled "The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma" for consideration at eLife.
We demonstrated that emc is also an important differentiation determinant in rbf1 mutant eyes, validating the use of Drosophila as a valuable tool for identifying factors that are important for the pRB/E2F pathway.
The manuscript entitled "The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma" investigates the role of the transcription factor PTF1A in the adult pancreas, including acinar cell maintenance, tissue repair following the induction of pancreatitis and carcinogenesis.
Although it is clear that TZDs are important differentiation determinants in our model cell line, we could show that DHEA does not inhibit PPARG expression in our model.
The C/EBPs in general are important regulators of cellular differentiation and determinants of terminal cell function.
Despite the progress made in characterizing hMSC differentiation, the molecular determinants that regulate osteogenesis are not completely understood.
Hence, analysis of their lineage, paths of differentiation, and molecular determinants may provide important insights into general mechanisms of self-renewal.
To rule out non-specific effects of depolarization and determine whether control of transmembrane potential is an instructive, bi-directional determinant of differentiation trajectory, we next asked whether hyperpolarization affected differentiation.
If Vmem is a true determinant of differentiation potential, as has been suggested [43], hyperpolarization ought to have the reverse effect of depolarization and thus induce differentiation.
Crucially, our functional results show that the relationship between depolarization and an undifferentiated state is not merely a correlation but rather that transmembrane potential is a functional determinant of differentiation state in hMSCs.
