More significantly still, in the 1960s Atiyah, the American Isadore Singer, and others found ways of connecting this work to the study of a wide variety of questions involving partial differentiation, culminating in the celebrated Atiyah-Singer theorem for elliptic operators.
We propose that failure to silence these LSK-associated genes in Lsd1 mutants interferes with proper differentiation, culminating in detrimental consequences for hematopoiesis (see Figure 7 for model).
Organophosphate (OP) pesticides damage the developing mammalian brain through multiple mechanisms that disrupt neural cell replication and differentiation, culminating in adverse effects on behavioral performance (Slotkin 1999, 2004, 2005).
The interfollicular epidermis is a multi-layered epithelium in which the basal layer of cells is attached to an underlying extracellular matrix (ECM), known as the basement membrane, and the suprabasal layers comprise cells that undergo terminal differentiation, culminating in formation of the barrier that protects the body from water loss and penetration by micro-organisms.
In large measure, the vulnerability of the fetus and neonate reflects interference with basic processes of neural cell replication and differentiation, culminating in aberrant synaptic function and associated behavioral deficits (Barone et al. 2000; Pope 1999; Rice and Barone 2000; Slotkin 2004).
The most persuasive genetic basis for a two-taxon model originates from a series of studies exploring patterns of differentiation at nuclear loci, culminating in a study using male inherited Y-chr, andbi-parentally inherited X-chr sequences [ 6] that concluded " there was a deep and almost complete separation between African forest and African savannah elephants".
Trials culminating in a leftward reach are shown in blue, while trials culminating in a rightward reach are shown in red.
It undergoes asexual reproduction (conidiation) in response to specific environmental cues via a series of cellular differentiation steps culminating in the production of asexual conidia (Boyce and Andrianopoulos 2013).
Thus, loss of Lsd1 culminates in a differentiation block at the transition of immature Gr1dim Mac1+ to mature Gr1high Mac1+ granulocytes.
The series culminated in a legendary fiasco.
