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Our data show high levels of among-population differentiation, consistent with the effects of historical demographic bottlenecks, local adaptation and climate effects.
Comparisons among geographically widespread populations of Desmophyllum dianthus showed high and statistically significant levels of genetic differentiation consistent with limited gene flow and isolation.
The AMOVA analysis also revealed similar structures of genetic differentiation consistent with the basic statistics (Table 3) when comparing the three genomes.
Importantly, PiT1, but not PiT2 is upregulated during osteoblast differentiation, consistent with a dedicated role of PiT1 in this process [15].
Phylogeographic studies of Ligia isopods in different parts of the world have revealed high levels of allopatric differentiation, consistent with expectations from their life history [11], [14].
These results also demonstrate that Prox1 expression is not dependent on Atoh1 or on hair cell differentiation consistent with recent reports, indicating autonomy of Prox1 expression from hair cell differentiation [4], [51].
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36 Therefore, our finding that expression of Dp53 suppresses cell differentiation is consistent with the inhibitory role of ΔN isoforms in cell differentiation.
The inhibitory effect of a LIFR antagonist on osteoblast differentiation is consistent with reports that the LIFR ligands LIF and CT-1 stimulate osteoblast differentiation and bone formation [23], [42] and that OSM, acting through LIFR in mice, stimulates bone formation [43].
Our finding that Sod2−/− skin expresses elevated levels of Tgm1, a marker of terminal keratinocyte differentiation is consistent with the increased thickness of Sod2−/− stratum corneum reflecting increased keratinocyte differentiation.
However, the P3 mice phenotype showed a general accelerated differentiation and, consistent with previous reports, exposed a key role for miR-24 in promoting HF differentiation.
Distinct heavy isotope ratios characterize all three sites and show regional differentiation broadly consistent with geological expectations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com