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For both the AS and CI models, this differentiation caused the total variance in the models to increase.
Exposure of PBMC to LPS, an inducer of inflammatory monocyte/macrophage (M1) differentiation caused increased miR-193b and miR222 and decreased miR27a, whereas exposure to IFN-γ, also considered an inflammatory monocyte/macrophage (M1) inducer, caused decreased miR-222, miR-125a-5p and miR-27a.
Therefore, the mean Fst of two populations displays the differentiation caused by a migration event.
Therefore, the potentiation of BMP-2 signaling at least in part contributes to the restoration of OB differentiation caused by the inhibition of TGF-β.
Since miR-24 overexpression is associated with differentiation (see introduction for detail) (Fig. 1 and 4), we suggest that the slow growth and differentiation caused by miR-24 overexpression contributes to MTX resistance.
It remains to be investigated whether the differential gene expression levels in the cartilage of Hoxc8- and Hoxd4-transgenic animals are proximally causal to the cartilage defects, or whether they are distal indicators of abnormal differentiation caused by overexpression of the transcription factors.
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This convoluted process of differentiation causes many companies to lose sight of the fact that, first and foremost, they need to solve a very compelling problem.
NSCs from the adult rodent and monkey brain express Hes3; differentiation causes a rapid loss of Hes3 expression [6].
On the other hand, sustained activation of β-catenin signaling specifically in the developing lung disrupts epithelial cell differentiation, causing enlargement of peripheral air spaces [15], [16].
Thus, muscular dystrophies associated with mutations in the A-type lamin gene, LMNA, may be associated with decreased satellite cell differentiation, causing depressed regeneration in addition to reduced myofiber stability.
Thus, if metallothionein proves to be the nuclear zinc ligand, we must consider the possibility that cellular differentiation causes an intracellular production of reactive oxygen species or is related to extracellular oxidative stress.
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