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Sex differentiation begins with differential expression of Sry and then Sox9 in the genital ridges at E10.5.
Sex differentiation begins in the embryo under genetic and hormonal control.
The next phase, one of differentiation, begins first in gonads that are to become testes and a week or so later in those destined to be ovaries.
After cardiomyocyte differentiation begins, reduction of FGF signaling can still result in a deficiency of ventricular cardiomyocytes.
Consistent with two temporally distinct roles for FGF, we find that increased FGF signaling induces a cardiomyocyte surplus only before cardiac differentiation begins.
The ideal moment of capture is just before that differentiation begins; these so-called pluripotent stem cells are coveted targets for collection and replication.
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One possibility is that this requirement is linked to structural constraints imposed on chromatin and/or nuclear architecture that occur in preparation for cell differentiation beginning at mesenchyme blastula stage.
Embryo maturation follows embryo pattern formation and differentiation, beginning at 15 DAP and lasting for about 30 days [ 15].
Sex differentiation began as early as 17 d.p.f., as indicated by the appearance of perinucleolar oocytes (POs; Figure 1a).
This stage more or less corresponds to 28-30 hpf in zebrafish, when atoh7 expression and RGC differentiation begin [ 23, 26].
The profile for the occipitoparietal region (Fig. 7 B ) shows a more sustained differentiation beginning at lag 1 and extending across the remaining temporal window.
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