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bHLH genes such as NeuroD and Math2 (Nex1) are expressed in differentiating neurons after neuronal fate determination.
Apoptosis of neuronal precursors and of differentiating neurons is a key process in CNS development.
Importantly, aberrant expression of REST in differentiating neurons causes repression of neuronal genes and leads to abnormal neuronal phenotypes [25], [26].
An important question is whether the cells undergoing apoptosis represent neuronal progenitors or differentiating neurons.
MiR-24 is upregulated in several cell types, including post-mitotic differentiation of hematopoietic cell lines, and differentiating neurons and myoblasts.
Alternatively, it is possible that differentiating neurons in the adult brain start to express mature neuronal genes at earlier steps in the pathway of neuron development than differentiating neurons in the embryonic brain.
In differentiating neurons, however, Hes1 expression disappears, leading to sustained expression of Ascl1, which induces neuronal differentiation.
Francis, F. et al. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.
The present study was designed to elucidate the cellular and molecular mechanisms of neuritogenesis in differentiating neurons.
Our results suggest that polymerization and depolymerization of actin by cofilin phosphorylation is necessary for neuritogenesis in differentiating neurons.
We developed a high resolution transcriptome (HRT) method to determine the full repertoire of transcripts in neural stem cells, migrating neurons, and differentiating neurons.
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