Sentence examples for differentiating agents from inspiring English sources
Subsequently, we examined whether adipogenic, osteogenic, or chondrogenic differentiation was induced by differentiating agents in these senesced 520d/NHDF cells treated with irradiation (77 days after transfection).
These differentiating agents activated various signaling pathways, thereby inducing various differentiated phenotypes and all resulting in decreased tumorigenicity.
The combined use of pharmacologic differentiating agents and growth factors may improve the clinical efficacy of differentiation therapy in APL.
These data demonstrate that both pharmacologic differentiating agents and myeloid growth factors are required, but neither sufficient, for the differentiation of APL cells.
Pharmacologic differentiating agents have had relatively limited clinical success outside of the use of ATRA in acute promyelocytic leukemia and DNA methyltransferase inhibitors in myelodysplastic syndromes.
In vitro and in vivo experimental evidences show that HDACi are able to resume the process of maturation in undifferentiated cancer cells, justifying their introduction as differentiating agents in several clinical trials.
In [11], authors highlight the software engineering benefits of differentiating agent aspect (the Agent-Centred Multi-Agent System or ACMAS) from social aspect (the Organization-Centred Multi-Agent System or OCMAS).
In other experiments, Py230 cells were plated at low density and treated with differentiating agent dimethyl sulfoxide (DMSO, Sigma-Aldrich) for 7 to 10 days, when outgrowth of mesenchymal cells could be observed.
In summary, we examined the rolling interactions of undifferentiated HL-60 leukaemic cells and HL-60 cells exposed to DMSO, a known terminal differentiating agent, over surfaces containing immobilized P-selectin Fc.
Loop-mediated isothermal amplification (LAMP) is widely used for differentiating causative agents in infectious diseases.
Taken together, these findings suggest that targeting the pleiotropic cellular functions of FAK may have a broad impact on the immuno-suppressive tumor microenvironment, differentiating these agents from many therapeutic approaches that target single immune cell populations.
