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Upon internalization, the elementary body (EB) differentiates into a noninfectious but metabolically active reticulate body (RB), which multiplies and subsequently differentiates back to an EB.
The protozoan parasite Entamoeba histolytica has two morphologically distinct life cycle forms, the infectious cyst form that transmits disease from person to person, and the trophozoite form that multiplies in the colon and eventually differentiates back into the cyst form.
Once the immune system is triggered, parasite growth is controlled, and the parasite differentiates back into the dormant bradyzoite cyst effectively hiding from the immune system, often in immune privileged areas such as the brain.
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Our finding that HOXB9 inducing expressions of tight junction protein shed light on the hope that enhancing the level of HOXB9 in colon adenocarcinoma cells may help to drive the de-differentiated cells to differentiate back to epithelial cells that hold low growth and invasion potentials.
It is not known whether there are stages of de-differentiation at which the cells can recover or re-differentiate back into fully mature β cells.
The program seems to take a page from Google's internal classes that helped it differentiate back in the day.
The ratio of self-renewing CSCs and the activity of non-CSCs to de-differentiate back to CSCs have been correlated with poor prognosis and clinical outcomes of cancers (Frank et al. 2010; Pece et al. 2010).
Preadipocytes have been shown to differentiate to macrophages, dedifferentiate from adipocytes, and differentiate back to adipocytes.
Approximately 20 h post infection (p.i ., the reticulate bodies start to differentiate back into a new generation of infectious EBs.
Infection is propagated further when the RBs differentiate back into EBs, which are released from the host cell by either exocytosis or lysis.
Induced pluripotent stem cells derived from human prostate and urinary tract cells can differentiate back into prostate and bladder cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com