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It is possible that autonomic responses may also become increasingly differentiated with increasing age.
Neural responses are generally thought to become increasingly fractionated and differentiated with increasing age, as cortical specialisation develops (Johnson, 2010).
To examine at which time point the RA enhancement of skeletal myogenesis was inhibited by β-Cat/EnR, RNA was harvested on days 0, 5 and 9 from P19 [control] and P19 [β-Cat/EnR] cultures differentiated with increasing amounts of RA.
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Human preadipocytes were differentiated as described with increasing concentrations of BPA for 14 days, and protein levels of the adipogenic marker aP2 were assessed by western blotting (a) and densitometry (b) analyses.
Interestingly, Rhim's study reported the occurrence of poorly differentiated tumors, with increased vascularity, and significantly reduced stromal content.
In human liver cancer, E-cadherin repression is more common in poorly differentiated cases with increased intrahepatic metastasis and poor prognosis [ 114].
The OR for observing a poorly differentiated tumor (grade 3-4) rathan than a well/moderately differentiated tumor (grade 1-2), wincreasingsing levels of an exposure variable (linear trend), was then estimated.
The proportion of poorly differentiated tumors decreased steadily with increasing age (Table 5).
Among parous women, the proportion of poorly differentiated tumors increased significantly with increasing parity, and decreased significantly with increasing age at first birth (Table 6).
To evaluate the role of the GHS-R1a receptor in the regulation of cholesterol efflux effectors in the macrophage, we treated PMA-differentiated THP-1 macrophages with increasing doses of ghrelin (1, 10, and 100 nM), and measured the expression of components of the PPARγ-LXRα-ABC pathway.
On univariate and multivariate analysis tumour differentiation correlated with TM expression, with increasing expression seen in well-differentiated tumours compared with moderate and poorly differentiated (P<0.001).
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